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FLASH GENE
Symbol FAM120B contributors: npt/mct - updated : 29-01-2010
HGNC name family with sequence similarity 120B
HGNC id 21109
Location 6q27      Physical location : 170.615.843 - 170.714.236
Synonym name
  • KIAA1838
  • PPARgamma constitutive coactivator-1
  • constitutive coactivator of peroxisome proliferator-activated receptor gamma
  • Synonym symbol(s) KIAA1838, PGCC1, dJ894D12.1, FLJ55614, KIAA0183, CCPG
    DNA
    TYPE functioning gene
    STRUCTURE 98.39 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3261 - 910 - Li (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine   
    Endocrineneuroendocrinepituitary   
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Respiratoryrespiratory tracttrachea   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four LXXLL motifs, which are characteristic for nuclear receptor coactivators (Li 2007)
  • HOMOLOGY
    interspecies ortholog to murine 4932442K08Rik
    Homologene
    FAMILY
  • constitutive coactivator of PPAR-gamma family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized in nucleus (Li 2007)
    basic FUNCTION
  • coactivator that promotes adipogenesis in a PPARgamma-dependent manner (Li 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the hinge region of PPARgamma in a ligand-independent manner (Li 2007)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS