Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CATSPER3

contributors: - updated : 21-09-2007

HGNC name	cation channel, sperm associated 3
HGNC id	20819

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q31.2      Physical location : 134.303.595 - 134.347.397
Synonym name	putative ion channel CatSper3, calcium channel repeat containing 1, one-repeat calcium channel-like gene
Synonym symbol(s)	CACRC

DNA

TYPE	functioning gene
SPECIAL FEATURE	opposite orientation
text	in head-to-tail orientation with DCOHM gene
STRUCTURE	43.00 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine large intestine colon       pharynx       highly Reproductive male system testis     predominantly   male system prostate     highly

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatid Reproductive spermatozoa Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	coiled-coil protein-protein interaction domains in the C-terminal tail
	a single-ion transport domain with six transmembrane spanning regions, in which the fourth transmembrane region resembles a voltage sensor and a pore-forming region lies between transmembrane regions 5 and 6

mono polymer

heteromer , tetramer

HOMOLOGY

intraspecies

homolog to CATSPER1, CATSPER2

Homologene

FAMILY

Catsper family

CATEGORY

receptor membrane ligand ion channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	voltage-gated Ca2+ channel
	forms a functional heterotetrameric channel in sperm (in association with Casper 1, 2 and 3)
	cation-channel protein having roles in acrosome reaction and male fertility

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule
	Ca2+ binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS