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FLASH GENE

Symbol

ADRA2A

contributors: mct/npt - updated : 30-05-2018

HGNC name	adrenergic, alpha-2A-, receptor
HGNC id	281

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to type 2 diabetes to attention deficit hyperactivity disorder (Gizer 2009) to decreased glucose-stimulated insulin response

Variant & Polymorphism SNP	a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk (Rosengren 2010)
	variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS