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FLASH GENE
Symbol ADRA2A contributors: mct/npt - updated : 30-05-2018
HGNC name adrenergic, alpha-2A-, receptor
HGNC id 281
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • adrenergic, alpha-2A-receptor, inhibiting formation of cAMP opening K+ channels, inhibiting Ca2+ channels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to type 2 diabetes
  • to attention deficit hyperactivity disorder (Gizer 2009)
  • to decreased glucose-stimulated insulin response
    • Variant & Polymorphism SNP
  • a single-nucleotide polymorphism in the human ADRA2A gene for which risk allele carriers exhibited overexpression of alpha(2A)AR, reduced insulin secretion, and increased type 2 diabetes risk (Rosengren 2010)
  • variants at the DGKB/AGMO, ADRA2A, GLIS3 and C2CD4B loci were associated with decreased glucose-stimulated insulin response
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS