SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| text
| translocated to plasma membrane through AP2 binding |
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synaptic vesicles |
| basic FUNCTION
| major protein of the polyhedral coat of coated pits and vesicles, involved in tumor development |
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may play a role in the hypotonia seen in velo-cardio-facial syndrome |
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is involved in the formation of insulin-responsive GLUT4 compartments in muscle and adipocytes  ) |
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functions in endosomal sorting at a distinct step from CLTC and is not observed on the mitotic spindle under normal conditions |
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endogenous CLTCL1 and CLTC function independently in nonmuscle and muscle cells |
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was required for retrograde trafficking of certain cargo molecules from endosomes to the trans-Golgi network (TGN), defining a novel endosomal-sorting step distinguishable from that mediated by CLTC and retromer |
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its function was not required for centrosome integrity, but its depletion caused multinucleation |
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CLTCL1 and SLC2A4 can be considered markers of muscle regeneration |
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essential and non-redundant role for CLTCL1 in neural crest development and in the genesis of pain and touch sensing neurons |
