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FLASH GENE
Symbol TRPC7 contributors: mct/npt/pgu - updated : 17-03-2010
HGNC name transient receptor potential cation channel, subfamily C, member 7
HGNC id 20754
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four ANK repeats
    • HOMOLOGY
    interspecies homolog to murine trp7
    intraspecies homolog to TRPC3 and TRPC6, which are also activated by DAG
    Homologene
    FAMILY
  • transient receptor family
  • STRPC subfamily
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text mostly associated to the surface of the spermatogenic cells
    basic FUNCTION
  • forming a receptor-activated non-selective calcium permeant cation channel
  • enhancing calcium influx independently of store depletion
  • may influence sperm motility
  • calcium (Ca2+) and magnesium (Mg2+) conducting channel, during proliferation of human osteoblasts
  • receptor-operated 1,2-diacylglycerol-activated channel in keratinocytes
  • would play important roles in Ca2+ signaling pathway through these characteristic features
  • additional function of TRPC3, and TRPC7 may be to enhance secretion either by affecting transport through the Golgi stack or by increasing fusion at the plasma membrane
  • necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin
    • NFAT signaling pathway
    CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component comprised of homo- or heterotetramers between TRPC3/6/7
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by by diacylglycerol (DAG), one of the PLC products, having high sequence homology with TRPC3 and TRPC6, which are also activated by DAG
    either Ca(2+) store depletion or phospholipase C activation
    Other expression and activity of TRPM7 is modulated by extracellular Mg2+ and Ca2+ availability, indicating that TRPM7 channels are involved in intracellular ion homeostasis and proliferation of osteoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS