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FLASH GENE

Symbol

TRPC7

contributors: mct/npt/pgu - updated : 17-03-2010

HGNC name	transient receptor potential cation channel, subfamily C, member 7
HGNC id	20754

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001167576 10 - 2589 NP_001161048 - 746 - 2004 15372022 NM_001167577 11 - 2752 NP_001161049 - 801 - 2004 15372022 NM_020389 12 - 2935 NP_065122 - 862 - 2004 15372022

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain diencephalon         brain hindbrain medulla oblongata     Reproductive male system testis     highly Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four ANK repeats

HOMOLOGY

interspecies

homolog to murine trp7

intraspecies

homolog to TRPC3 and TRPC6, which are also activated by DAG

Homologene

FAMILY	transient receptor family
	STRPC subfamily

CATEGORY

receptor membrane , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	mostly associated to the surface of the spermatogenic cells

basic FUNCTION	forming a receptor-activated non-selective calcium permeant cation channel
	enhancing calcium influx independently of store depletion
	may influence sperm motility
	calcium (Ca2+) and magnesium (Mg2+) conducting channel, during proliferation of human osteoblasts
	receptor-operated 1,2-diacylglycerol-activated channel in keratinocytes
	would play important roles in Ca2+ signaling pathway through these characteristic features
	additional function of TRPC3, and TRPC7 may be to enhance secretion either by affecting transport through the Golgi stack or by increasing fusion at the plasma membrane
	necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin
	NFAT signaling pathway

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

comprised of homo- or heterotetramers between TRPC3/6/7

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by	by diacylglycerol (DAG), one of the PLC products, having high sequence homology with TRPC3 and TRPC6, which are also activated by DAG
	either Ca(2+) store depletion or phospholipase C activation

Other

expression and activity of TRPM7 is modulated by extracellular Mg2+ and Ca2+ availability, indicating that TRPM7 channels are involved in intracellular ion homeostasis and proliferation of osteoblasts

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS