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FLASH GENE
Symbol PRKG2 contributors: mct - updated : 07-11-2012
HGNC name protein kinase, cGMP-dependent, type II
HGNC id 9416
Corresponding disease
DEL4Q21 chromosome 4q21 microdeletion syndrome
Location 4q21.21      Physical location : 82.009.836 - 82.126.215
Synonym symbol(s) CGPK2, PRKGR2, cGKII
EC.number 2.7.11.12
DNA
TYPE functioning gene
STRUCTURE 116.38 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3328 - 762 - 2008 18656450
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Nervousbraindiencephalonamygdala   Homo sapiens
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two cyclic nucleotide-binding domains
  • a protein kinase domain
  • leucine zipper (LZ) domain, and LZ residues 40-83 dimerized and specifically interacted with RAB11B
  • HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, CGMP subfamily
    CATEGORY regulatory , receptor membrane tyrosine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • putatively involved in regulation of intestinal fluid secretion
  • is potentially important for the NPPC-mediated endochondral ossification
  • NPR1 and PRKG2 are selectively induced in granulosa cells of preovulatory follicles by LH- and PR-dependent mechanisms, thereby providing a pathway for cGMP function during ovulation
  • involved in controlling anxiety-like behavior
  • inhibits cell proliferation, SOX9 expression and AKT1 phosphorylation in glioma cell lines
  • major cGMP effector in the gut epithelium
  • antiproliferative and prodifferentiation role for PKG2 in the colon
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB11B is necessary for the trafficking of PRKG2 and the cGMP/PRKG2 signaling pathway is closely related to RAB11B recycling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL4Q21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Prkg2(-/-) mice) develop dwarfism as a result of impaired endochondral ossification