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FLASH GENE
Symbol TXNRD3 contributors: npt - updated : 09-02-2006
HGNC name thioredoxin reductase 3
HGNC id 20667
Location 3p13-q13.33      Physical location : 126.325.894 - 126.373.967
Synonym name
  • thioredoxin reductase TR2
  • thioredoxin glutathione reductase
  • thioredoxin reductase 2
  • Synonym symbol(s) TR2, TRXR3, TGR
    DNA
    TYPE functioning gene
    STRUCTURE 49.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    SNX4 3q21.1-q21.3 sorting nexin 4 OSBPL11 3q21 oxysterol binding protein-like 11 LOC389144 3 similar to seven transmembrane helix receptor OR7E93P 3q13.33 olfactory receptor, family 7, subfamily E, member 93 pseudogene OR7E53P 3q13.33 olfactory receptor, family 7, subfamily E, member 53 pseudogene OR7E97P 3q13.33 olfactory receptor, family 7, subfamily E, member 97 pseudogene LOC344729 3q21.2 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 LOC389145 3 LOC389145 LOC165622 3q21.2 similar to Alkaline sphingomyelinase LOC200810 3q21.2 similar to asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); beta-1,4 mannosyltransferase LOC152015 3q21.2 similar to AKAP-binding sperm protein ropporin FLJ20473 FTHFD 3q21.2 formyltetrahydrofolate dehydrogenase KLF15 3q13-q21 Kruppel-like factor 15 FLJ40083 3q21.3 hypothetical protein FLJ40083 FLJ20123 3q21.3 hypothetical protein FLJ20123 MGC11349 3q21.3 hypothetical protein MGC11349 FLJ31300 3q21.3 hypothetical protein FLJ31300 CHST13 3q21.3 carbohydrate (chondroitin 4) sulfotransferase 13 MGC34728 3q21.3 hypothetical protein MGC34728 TXNRD3 3p13-q13.33 thioredoxin reductase 3 LOC255330 3q21.3 hypothetical protein LOC255330 LOC391571 3 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) MGC13016 DKFZp564A176 3q21.3 hypothetical protein DKFZp564A176 LOC285311 3q21.3 hypothetical gene supported by AK097460 TPRA40 3q21.2 seven transmembrane domain orphan receptor MCM2 3q21 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) PODLX2 15 endoglycan ABTB1 3q21 ankyrin repeat and BTB (POZ) domain containing 1 MGLL 3q21.3 monoglyceride lipase
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a FAD-binding domain
  • a NADPH-binding domain
  • conjugated FlavoP
    HOMOLOGY
    interspecies homolog to rattus LOC297437
    ortholog to murine Txnrd3
    ortholog to dog LOC484619
    Homologene
    FAMILY
  • pyridine nucleotide-disulfide oxidoreductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting on NADH or NADPH as acceptor
  • may have an essential role in redox-regulated cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • FAD
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS