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FLASH GENE
Symbol USP17 contributors: mct/npt - updated : 08-07-2009
HGNC name ubiquitin specific peptidase 17
HGNC id 12615
Location 4p16.1      Physical location : 9.217.130 - 9.366.446
Synonym name
  • megasatellite sequence RS447, highly repetitive
  • ubiquitin specific protease 17
  • deubiquitinating enzyme 17
  • ubiquitin thioesterase 17-like protein 2
  • ubiquitin thioesterase 17-like protein 5
  • Synonym symbol(s) RS447, DUB3, MGC119330, MGC119331, MGC119333
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text head to head tandem structure
    STRUCTURE 1.59 kb     1 Exon(s)    several Copie(s)
    motif repetitive sequence
    text structure number but not all of the 17 to 95 repeats maybe transcribed (RS447 megasatellite, hypervariable)
  • unique expression pattern in that its complementary strand is transcribed as an antisense transcript that may modulate the level of USP17 expression in the brain
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text an antisense transcript
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1593 - 530 - Burrows (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas   highly
    cell lineage
    cell lines moderately in various human cancerous cell lines (Shin 2006)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six conserved domains found in the minimum catalytic core of deubiquitinating enzyme
  • putative hyaluronan/RNA binding motifs, playing an important role in regulating signal transduction involved in cell death (Shin 2006)
  • HOMOLOGY
    interspecies homolog to conserved (in the mammals)
    ortholog to murine Dub1
    ortholog to murine Dub2
    Homologene
    FAMILY
  • peptidase C19 family
  • USP17 subfamily
  • CATEGORY enzyme , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,nucleolus
    text with RCE1 co-localize at the endoplasmic reticulum (Burrows 2009)
    basic FUNCTION
  • suppression of protein degradation
  • cytokine-inducible immediate early genes
  • blocks RAS membrane localization and activation, thereby inhibiting phosphorylation of the downstream kinases MEK and ERK (Burows 2009)
  • modulates Ras processing and activation, at least in part, by regulating RCE1 activity (Burows 2009)
  • disrupts RAS plasma membrane localization and activation and markedly inhibits proliferation ((Burows 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negatively regulates the activity of RCE1 (cleavage of CAAX domain of RAS) (Burows 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS