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FLASH GENE
Symbol CYP26C1 contributors: shn - updated : 03-06-2012
HGNC name cytochrome P450, family 26, subfamily C, polypeptide 1
HGNC id 20577
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Cyp26c1, Mus musculus
ortholog to Cyp26c1, Rattus norvegicus
ortholog to cyp26c1, Danio rerio
intraspecies homolog to CYP26B1
Homologene
FAMILY cytochrome P450 family
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may play a specific role in catabolizing both all-trans and 9-cis isomers of retinoic acid (
  • required for correct A-P patterning and production of migratory cranial neural crest cells in the developing brain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text Metabolism of 9-cis and All-trans Isomers of Retinoic Acid (
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FFDD4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • nonsyndromic optic nerve aplasia (
    • Marker
    Therapy target
    ANIMAL & CELL MODELS