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FLASH GENE
Symbol WFDC10B contributors: mct/npt - updated : 15-07-2008
HGNC name WAP four-disulfide core domain 10B
HGNC id 20479
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
 male systemmale genital tractepididymis  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a WFDC domain, or WAP signature motif
  • eight cysteines forming four disulfide bonds at the core of the protein, and functioning as a protease inhibitor
    • HOMOLOGY
    Homologene
    FAMILY
  • WAP-type fouor disulfide core (WFDC) family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease inhibitor, epididymal gene that contribute to the regulation of sperm maturation by regulating the proteolytic processing of the sperm membrane during epididymal transit
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS