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FLASH GENE

Symbol

WFDC10B

contributors: mct/npt - updated : 15-07-2008

HGNC name	WAP four-disulfide core domain 10B
HGNC id	20479

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.12      Physical location : 44.313.290 - 44.333.658
Synonym name	protease inhibitor WAP12
Synonym symbol(s)	WAP12

DNA

TYPE	functioning gene
STRUCTURE	20.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Binding site

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

in the telomeric cluster of WFDC genes

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 632 8 73 - Clauss (2005) secreted protein variant 2 - - 477 - 89 - Clauss (2005) lacks an internal exon and the resulting isoform (an intracellular protein) lacks a signal peptide

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis         male system male genital tract epididymis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a WFDC domain, or WAP signature motif
	eight cysteines forming four disulfide bonds at the core of the protein, and functioning as a protease inhibitor

HOMOLOGY

Homologene

FAMILY

WAP-type fouor disulfide core (WFDC) family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

protease inhibitor, epididymal gene that contribute to the regulation of sperm maturation by regulating the proteolytic processing of the sperm membrane during epididymal transit

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS