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FLASH GENE

Symbol

TRAF7

contributors: mct/npt/pgu - updated : 05-09-2018

HGNC name	TNF receptor-associated factor 7
HGNC id	20456

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032271 21 - 3676 NP_115647 - 670 - 2004 15001576

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Reproductive female system uterus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal cys/his-rich region
	a RING-type zinc finger
	a coiled-coil motif, required for association with IKBKG
	a TRAF domain
	lacks the conserved C-terminal domain found in TRAF1–6, and instead it has several WD40 repeats in its C-terminal domain , C-terminal WD40 domain has been shown to facilitate TRAF7 interaction with MAP3K3

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

tumor necrosis factor receptor-associated factor (TRAF) protein family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	may have E3 ubiquitin ligase activity
	potentiates MAP3K3-induced AP1 and CHOP activation
	induces caspase-dependent apoptosis when overexpressed
	involved in MAP3K3 signaling and apoptosis
	potentiated MAP3K3-mediated AP1 and CHOP activation and induced apoptosis through distinct domains
	negatively regulates MYB activity by sequestering MYB to the cytosol via sumoylation
	involved in the signal transduction pathway that links Toll-like receptor 2 stimulation to activation of NFKB transcription factor
	TRAF7 also influences RELA nuclear distribution
	negative role for TRAF7 in NFKB signaling
	acts as a negative regulator of NFKBB and functions as a positive regulator of AP1
	important role for TRAF7 in the activation of JNK following TNF stimulation and clearly point to an involvement of this protein in regulating the turnover of CFLAR and, consequently, cell death
	is involved in signal transduction pathways that lead either to activation or repression of NFKB1 transcription factor
	E3 ubiquitin ligase for several proteins involved in the activation of TLR-dependent NF-kappaB signaling

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to MYB and stimulates its sumoylation (bound to the DNA-binding domain of MYB via its WD40 repeats and TRAF7 has an E3 ubiquitin ligase activity for self-ubiquitination)
	direct MYOD1 target
	IKBKG, the NF-KB essential modulator, is a TRAF7-interacting protein
	interacting with IKBKG, and RELA (promotes Lys-29-linked polyubiquitination of IKBKG and RELA that results in lysosomal degradation of both proteins and altered activation)
	TRAF7-mediated ubiquitination of TP53 plays a critical role in breast cancer development
	TRAF7 interacts by its WD40 domain with MAP3K3 and coexpression of TRAF7 with MAP3K3 activates the JNK and MAPK14 signaling pathways that affect cell proliferation, differentiation, survival, and migration
	TRAF7 links TNFR family proteins to signaling pathways, thus participates in regulating cell death and survival mediated by TNF family ligands

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRSHDL

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   accelerates myogenesis, in part through downregulation of nuclear factor-kappaB (NF-KB) activity tumoral somatic mutation       in adenomatoid tumors of the male and female genital tracts tumoral germinal mutation       in 60p100 of intraneural perineuriomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS