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FLASH GENE

Symbol

TREML1

contributors: mct - updated : 23-09-2015

HGNC name	triggering receptor expressed on myeloid cells-like 1
HGNC id	20434

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   therapeutic modulation of TLT-1-mediated effects may provide clinical benefit to patients with hypercoagulatory conditions, including those associated with inflammation

ANIMAL & CELL MODELS

	Tlt-1 null mice exhibit deficiency in platelet aggregation and are susceptible to lipopolysaccharide-induced septic shock
	platelets of Treml1-/- mice failed to aggregate efficiently, extending tail-bleeding times