Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TREML1 contributors: mct - updated : 23-09-2015
HGNC name triggering receptor expressed on myeloid cells-like 1
HGNC id 20434
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmegakaryocyte Homo sapiens
Blood/Hematopoieticplatelet Homo sapiens
Lymphoid/Immunemacrophage Homo sapiens
Skeletonosteoclast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular Ig domain
  • a proline-rich region
  • contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain capable of recruiting protein-tyrosine phosphatases
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY TREM family
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • abundant platelet-specific, type I transmembrane receptor
  • membrane protein receptor found in alpha-granules of platelets and megakaryocytes
    • basic FUNCTION
  • may regulate the signaling of the TREM family receptors (TLT-1)
  • type 1 single Ig domain orphan receptor specific to platelet and megakaryocyte alpha-granules, relocating to the platelet surface upon platelet stimulation
  • plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury
  • during inflammation, soluble isoform may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium
  • facilitate platelet aggregation through binding to fibrinogen
  • soluble TREML1 is important in regulating leukocyte activation during other noninfectious inflammatory disorders
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    therapeutic modulation of TLT-1-mediated effects may provide clinical benefit to patients with hypercoagulatory conditions, including those associated with inflammation
    ANIMAL & CELL MODELS
  • Tlt-1 null mice exhibit deficiency in platelet aggregation and are susceptible to lipopolysaccharide-induced septic shock
  • platelets of Treml1-/- mice failed to aggregate efficiently, extending tail-bleeding times