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FLASH GENE

Symbol

CALR3

contributors: mct/npt - updated : 10-12-2013

HGNC name	calreticulin 3
HGNC id	20407

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CMH19

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer tissues (particularly melanoma)(Hayashi 2007)

Susceptibility

to familial hypertrophic cardiomyopathy (Chiu 2007)

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception reproduction fertility   manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility

ANIMAL & CELL MODELS

	murine Calr3(-/-) males produced apparently normal sperm but were infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida