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FLASH GENE
Symbol CALR3 contributors: mct/npt - updated : 10-12-2013
HGNC name calreticulin 3
HGNC id 20407
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Calr3
intraspecies homolog to testis-specific homologs of CALR
Homologene
FAMILY
  • calreticulin family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • endoplasmic and sarcoplasmic reticulum
  • CLGN is membrane-anchored whereas CALR3 is soluble
    • basic FUNCTION
  • calcium ion storage activity
  • lectin-deficient chaperone directly required for ADAM3A maturation
  • testis-specific calreticulin homologs CLGN and CALR3 have distinct but cooperative roles in the maturation of ADAM3A during spermatogenesis and subsequent sperm fertilizing ability
    • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly associates with ADAM3A and controls its maturation
  • PDILT cooperates with CALR3, in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
  • recognizes ADAM3A with the aid of PDILT and the complex promotes ADAM3A maturation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMH19
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer tissues (particularly melanoma)(Hayashi 2007)
    Susceptibility to familial hypertrophic cardiomyopathy (Chiu 2007)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception
    reproductionfertility 
    manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility
    ANIMAL & CELL MODELS
  • murine Calr3(-/-) males produced apparently normal sperm but were infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida