Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

CALR3

contributors: mct/npt - updated : 10-12-2013

HGNC name	calreticulin 3
HGNC id	20407

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.13 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145046 9 - 1285 NP_659483 - 384 - 2007 17975137

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Homo sapiens Reproductive spermatid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Calr3

intraspecies

homolog to testis-specific homologs of CALR

Homologene

FAMILY

calreticulin family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	endoplasmic and sarcoplasmic reticulum
	CLGN is membrane-anchored whereas CALR3 is soluble

basic FUNCTION	calcium ion storage activity
	lectin-deficient chaperone directly required for ADAM3A maturation
	testis-specific calreticulin homologs CLGN and CALR3 have distinct but cooperative roles in the maturation of ADAM3A during spermatogenesis and subsequent sperm fertilizing ability

CELLULAR PROCESS	protein, post translation
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	directly associates with ADAM3A and controls its maturation
	PDILT cooperates with CALR3, in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and folding of ADAM3A
	recognizes ADAM3A with the aid of PDILT and the complex promotes ADAM3A maturation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMH19

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cancer tissues (particularly melanoma)(Hayashi 2007)

Susceptibility

to familial hypertrophic cardiomyopathy (Chiu 2007)

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction contraception   manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for contraception reproduction fertility   manipulation of the testis-specific CLGN/CALR3 ER quality control system could be exploited to develop novel therapeutic approaches for treatment of male infertility

ANIMAL & CELL MODELS

	murine Calr3(-/-) males produced apparently normal sperm but were infertile because of defective sperm migration from the uterus into the oviduct and defective binding to the zona pellucida