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FLASH GENE
Symbol PRMT2 contributors: mct/npt/pgu - updated : 17-04-2015
HGNC name protein arginine methyltransferase 2
HGNC id 5186
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SRC homology 3 domain in the N terminal region
  • the alternatively spliced C-terminus of PRMT2 can directly influence its subcellular localization
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae MMT1 like 1
    Homologene
    FAMILY
  • protein arginine N methyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text in the presence of androgens with AR colocalize and translocate into the nucleus
    basic FUNCTION
  • arginine methyltransferase transferring a methyl group from S adenosyl methionine to the guanidino group nitrogen atoms of specific proteins
  • acts as AR-coactivator, presumably by arginine methylation
  • coactivator of estrogen receptor alpha
  • new member of the NFKB1 pathway controlling LPS-induced inflammatory and lung responses in a dosage-dependent manner
  • PRMT2 and its splice variants may directly modulate ESR1 signaling and play a role in the progression of breast cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • S-adenosylmethionine dependent
    • protein
  • enhancing ESR1
  • also binding ESR2, PR, TRbeta, RAR alpha, PPAR gamma, RXR alpha
  • interacting with the coactivators NCOA1 and NCOA6
  • acting as a strong coactivator of the AR, had modest or none influence on transcriptional activation mediated by other nuclear receptors
  • binding to hnRNP (heterogeneous nuclear riboproteins)
  • PRMT1 serves as the major methyltransferase in cells by forming higher-order oligomers with itself, PRMT2, and possibly other PRMTs
  • COBL-mediated dendritic arborization required PRMT2, complex formation with PRMT2, and PRMT2 catalytic activity (pMID: 29689199)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for dyslexia
    Marker
    Therapy target
    ANIMAL & CELL MODELS