Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GSX1 contributors: mct/npt - updated : 15-06-2009
HGNC name GS homeobox 1
HGNC id 20374
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one homeobox domain
    • HOMOLOGY
    interspecies homolog to murine Gsh1
    Homologene
    FAMILY
  • Antp homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a key role in the expression of GHRH gene and an important role in pituitary development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'
    RNA
    small molecule
    protein
  • interacting with TXN2 (TXN2 and GSX1 systems are both functionally important at low oxidative stress conditions) (Zhang 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    non-proneural requirement of Ascl1 that together with Gsx1 compensates for the loss of Gsx2 in a subset of lateral ganglionic eminence progenitors, in mice (Wang 2009)