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FLASH GENE

Symbol

GSX1

contributors: mct/npt - updated : 15-06-2009

HGNC name	GS homeobox 1
HGNC id	20374

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	1.31 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 2 - 847 isoform 1 27 264 - Mutsuga (2001)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one homeobox domain

HOMOLOGY

interspecies

homolog to murine Gsh1

Homologene

FAMILY

Antp homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

playing a key role in the expression of GHRH gene and an important role in pituitary development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'

RNA

small molecule

protein

interacting with TXN2 (TXN2 and GSX1 systems are both functionally important at low oxidative stress conditions) (Zhang 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

non-proneural requirement of Ascl1 that together with Gsx1 compensates for the loss of Gsx2 in a subset of lateral ganglionic eminence progenitors, in mice (Wang 2009)