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FLASH GENE

Symbol

RASA3

contributors: mct - updated : 27-02-2015

HGNC name	RAS p21 protein activator 3
HGNC id	20331

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	in mice, reduced expression of Rasa3 led to premature platelet activation and markedly reduced the life span of circulating platelets
	Rasa3 catalytic inactivation in mouse hematopoietic cells results in a lethal syndrome characterized by severe defects during megakaryopoiesis, thrombocytopenia and a predisposition to develop preleukemia
	scat phenotype is due to a mutation in Rasa3 with its mislocalization leading to its loss of function, and to crisis and remission episodes