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FLASH GENE
Symbol ZIC5 contributors: - updated : 05-06-2006
HGNC name Zic family member 5 (odd-paired homolog, Drosophila)
HGNC id 20322
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four C2H2-type zinc fingers
  • a proline-rich domain
  • an alanine-rich domain
    • HOMOLOGY
    interspecies homolog to rattus LOC361095
    ortholog to murine Zic5
    homolog to xenopus zic5-A
    Homologene
    FAMILY GLI C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text nuclear localization of ZIC4/ZIC5 not affected by the presence of MDFI
    basic FUNCTION may be involved in development
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    X-linked visceral heterotaxy and holoprosencephaly type 5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS