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FLASH GENE
Symbol SMOC1 contributors: mct - updated : 05-02-2011
HGNC name SPARC related modular calcium binding 1
HGNC id 20318
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a follistatin-like domain
  • a SMOC domain
  • two thyroglobulin-like domains
  • one extracellular calcium binding domain with two EF-hand motifs
  • three potential N-glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Smoc1
    Homologene
    FAMILY
  • SPARC family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • with SMOC2 are matricellular proteins thought to influence growth factor signaling, migration, proliferation, and angiogenesis
  • may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
  • regulator of osteoblast differentiation of bone marrow derived mesenchymal stem cells
  • essential player in both ocular and limb development and give further support to the crucial roles of BMP signaling in these systems
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ binding
    • protein
    cell & other
    REGULATION
    Other calcium-dependent conformation
    ASSOCIATED DISORDERS
    corresponding disease(s) OPACS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Smoc1 null mice recapitulated MLA phenotypes, including aplasia or hypoplasia of optic nerves, hypoplastic fibula and bowed tibia, and syndactyly in limbs