Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TFDP2 contributors: mct - updated : 14-05-2018
HGNC name transcription factor Dp-2 (E2F dimerization partner 2)
HGNC id 11751
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
 salivary gland   highly
Lymphoid/Immunelymph node   highly
 thymus   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a heterodimerization domain
  • a DNA binding domain
  • a typical RRXYD E2F DNA recognition motif in the DNA binding domain
  • a C terminus composed of multiple acidic amino acids (15 of the last 20 amino acids are acidic
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY E2F/DP family, transcription factor dimerization partner (DP) family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • DP2/E2F complex functioning in the control of cell-cycle progression from G1 to S phase
  • the E2F-1/DP complex appears to mediate both cell
    • proliferation and apoptosis
  • is a critical cofactor required for proper cell cycle control and gene expression
  • importance of TFDP2 in coupling the erythroid cell cycle with terminal differentiation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimerizing with E2F family members
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (p107 and p130)
    that inhibit the E2F transactivation domain
  • role of PRPF39 as a potential regulator of TFDP2 represents an interesting area of further study regarding the role of TFDP2 and cisplatin response
  • GATA1 and TAL1 are bound to the regulatory regions of TFDP2 and upregulate its expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS