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FLASH GENE

Symbol

TFDP2

contributors: mct - updated : 14-05-2018

HGNC name	transcription factor Dp-2 (E2F dimerization partner 2)
HGNC id	11751

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	77.00 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001178139 13 - 9908 NP_001171610 49.2 446 - 1996 8755520 NM_001178138 14 - 9946 NP_001171609 43 386 - 1996 8755520 NM_001178141 10 - 9337 NP_001171612 39.2 349 - 1996 8755520 NM_006286 11 - 9462 NP_006277 43 386 - 1996 8755520 NM_001178140 10 - 9404 NP_001171611 46.3 418 - 1996 8755520 NM_001178142 8 - 9185 NP_001171613 34.7 310 - 1996 8755520

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly   salivary gland       highly Lymphoid/Immune lymph node       highly   thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a heterodimerization domain
	a DNA binding domain
	a typical RRXYD E2F DNA recognition motif in the DNA binding domain
	a C terminus composed of multiple acidic amino acids (15 of the last 20 amino acids are acidic

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

E2F/DP family, transcription factor dimerization partner (DP) family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus,nucleoplasm

basic FUNCTION	DP2/E2F complex functioning in the control of cell-cycle progression from G1 to S phase
	the E2F-1/DP complex appears to mediate both cell
	proliferation and apoptosis
	is a critical cofactor required for proper cell cycle control and gene expression
	importance of TFDP2 in coupling the erythroid cell cycle with terminal differentiation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimerizing with E2F family members

INTERACTION

DNA

RNA

small molecule

protein	interact with hypophosphorylated retinoblastoma protein RB1 and related proteins (p107 and p130)
	that inhibit the E2F transactivation domain
	role of PRPF39 as a potential regulator of TFDP2 represents an interesting area of further study regarding the role of TFDP2 and cisplatin response
	GATA1 and TAL1 are bound to the regulatory regions of TFDP2 and upregulate its expression

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS