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FLASH GENE
Symbol SMEK1 contributors: mct - updated : 05-10-2013
HGNC name SMEK homolog 1, suppressor of mek1 (Dictyostelium)
HGNC id 20219
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an EVH1 domain at its N terminus during vegetative growth
  • a nuclear localization signal (NLS) at its C terminus
  • a WH1 domain
    • HOMOLOGY
    Homologene
    FAMILY SMEK family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be involved in carbohydrate metabolism
  • required for proper cytokinesis during vegetative growth, timely exit from the mound stage during development, and myosin II assembly
  • regulatory subunit of protein phosphatase 4 (PP4) complex, playing an important role in histone deacetylation and silencing of the Wnt-responsive gene, brachyury, in embryonic stem cells
  • SMEK1-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMEK1/PPP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2
  • ZMYND10 directly interacts with SMEK1, a regulatory subunit of protein phosphatase 4 (N-terminus of ZMYND10 was observed to interact with the C-terminal of SMEK1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS