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FLASH GENE

Symbol

SMEK1

contributors: mct - updated : 05-10-2013

HGNC name	SMEK homolog 1, suppressor of mek1 (Dictyostelium)
HGNC id	20219

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	52.94 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032560 16 - 3894 NP_115949 - 820 - 2005 1610772 the longest isoform NM_001284281 - - 3896 NP_001271210 - 594 - 2005 1610772 a distinct CDS and a 3'UTR resulting in a shorter isoform NM_001284280 - - 4574 NP_001271209 - 820 - 2005 1610772

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune lymph node       highly Reproductive female system uterus     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an EVH1 domain at its N terminus during vegetative growth
	a nuclear localization signal (NLS) at its C terminus
	a WH1 domain

HOMOLOGY

Homologene

FAMILY

SMEK family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	may be involved in carbohydrate metabolism
	required for proper cytokinesis during vegetative growth, timely exit from the mound stage during development, and myosin II assembly
	regulatory subunit of protein phosphatase 4 (PP4) complex, playing an important role in histone deacetylation and silencing of the Wnt-responsive gene, brachyury, in embryonic stem cells
	SMEK1-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SMEK1/PPP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2
	ZMYND10 directly interacts with SMEK1, a regulatory subunit of protein phosphatase 4 (N-terminus of ZMYND10 was observed to interact with the C-terminal of SMEK1)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS