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FLASH GENE
Symbol SMEK1 contributors: mct - updated : 05-10-2013
HGNC name SMEK homolog 1, suppressor of mek1 (Dictyostelium)
HGNC id 20219
Location 14q32.12      Physical location : 91.923.957 - 91.976.644
Synonym name
  • serine/threonine-protein phosphatase 4 regulatory subunit 3A
    • Synonym symbol(s) FLJ20707, MSTP033, FLFL1, KIAA2010, smk-1, smk1, PP4R3A
    DNA
    TYPE functioning gene
    STRUCTURE 52.94 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3894 - 820 - 2005 1610772
    the longest isoform
    - - 3896 - 594 - 2005 1610772
    a distinct CDS and a 3'UTR resulting in a shorter isoform
    - - 4574 - 820 - 2005 1610772
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemuterus  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an EVH1 domain at its N terminus during vegetative growth
  • a nuclear localization signal (NLS) at its C terminus
  • a WH1 domain
    • HOMOLOGY
    Homologene
    FAMILY SMEK family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be involved in carbohydrate metabolism
  • required for proper cytokinesis during vegetative growth, timely exit from the mound stage during development, and myosin II assembly
  • regulatory subunit of protein phosphatase 4 (PP4) complex, playing an important role in histone deacetylation and silencing of the Wnt-responsive gene, brachyury, in embryonic stem cells
  • SMEK1-containing PP4 complex represses transcription of Wnt-responsive development-related genes through histone deacetylation, and that this complex is essential for ESC pluripotency maintenance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMEK1/PPP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2
  • ZMYND10 directly interacts with SMEK1, a regulatory subunit of protein phosphatase 4 (N-terminus of ZMYND10 was observed to interact with the C-terminal of SMEK1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS