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| Pitx2 gene-deleted mice display defective body-wall closure, right pulmonary isomerism, altered cardiac position, arrest in turning and a block in the determination and proliferation events of anterior pituitary gland and tooth organogenesis ( | |
Pitx2-/- mice embryos had correctly oriented, but arrested, embryonic rotation and right pulmonary isomerism, defective development of the mandibular and maxillary facial prominences, regression of the stomodeum and arrested tooth development ( |
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Complete Pitx2 loss of function in mice results in agenesis or severe disruption of periocular mesenchyme structures and extrinsic defects in early optic nerve development ( |
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neural crest-specific Pitx2 knockout mice are viable and exhibit an optic nerve phenotype in which the eyes are progressively displaced towards the midline until they are directly attached to the ventral hypothalamus ( |
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ablation of unilateral Pitx2 expression in mice impairs asymmetric remodelling of the branchial arch artery system, resulting in randomized laterality of the aortic arch |
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Pitx2c-deficient mice do not develop a pulmonary myocardial sleeve because they fail to form the initial pulmonary myocardial cells |