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FLASH GENE
Symbol USP44 contributors: mct - updated : 04-02-2015
HGNC name ubiquitin specific protease 44
HGNC id 20064
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain
  • a conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes
    • HOMOLOGY
    interspecies homolog to rattus LOC314746
    Homologene
    FAMILY peptidase family c19
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in ubiquitin-dependent protein catabolism
  • important role for USP44 in regulating CDC20-APC/C activity, suggesting that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemia
  • RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
  • inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry
  • regulated the mitotic checkpoint and prevented chromosome lagging
  • prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint
    • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can cleave ubiquitin from ubiquitinated substrate
  • deubiquitinase USP44 is a negative regulator of H2B ubiquitylation, whose downregulation during ESC differentiation contributes to the increase in H2Bub1
  • USP44 implicated in negative regulation of the RNF8/RNF168 pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis (
  • mice lacking Usp44 were prone to the development of spontaneous tumors, particularly in the lungs