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FLASH GENE

Symbol

USP44

contributors: mct - updated : 04-02-2015

HGNC name	ubiquitin specific protease 44
HGNC id	20064

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	34.93 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032147 6 - 4032 NP_115523 - 712 - 2004 14715245 NM_001042403 6 - 3890 NP_001035862 - 712 - 2004 14715245 NM_001278393 6 - 4106 NP_001265322 - 712 - 2004 14715245

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Mus musculus   liver         Mus musculus   stomach         Mus musculus Endocrine pancreas         Mus musculus Reproductive male system testis       Respiratory lung         Mus musculus Skin/Tegument skin         Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain
	a conserved cysteine, histidine and asparagine/aspartic acid residues characteristic of deubiquitinating enzymes

HOMOLOGY

interspecies

homolog to rattus LOC314746

Homologene

FAMILY

peptidase family c19

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus,nucleolus

basic FUNCTION	involved in ubiquitin-dependent protein catabolism
	important role for USP44 in regulating CDC20-APC/C activity, suggesting that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemia
	RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
	inhibited chromosome segregation errors independent of its role in the mitotic checkpoint by regulating centrosome separation, positioning, and mitotic spindle geometry
	regulated the mitotic checkpoint and prevented chromosome lagging
	prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint

CELLULAR PROCESS	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	can cleave ubiquitin from ubiquitinated substrate
	deubiquitinase USP44 is a negative regulator of H2B ubiquitylation, whose downregulation during ESC differentiation contributes to the increase in H2Bub1
	USP44 implicated in negative regulation of the RNF8/RNF168 pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis (
	mice lacking Usp44 were prone to the development of spontaneous tumors, particularly in the lungs