SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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text
| localizes to ER-derived membranes, primarily the Golgi apparatus, but not exclusively in mitochondria |
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localizes to both the outer mitochondrial membrane and the plasma membrane |
basic FUNCTION
| ABC transporter, traffic ATPase |
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transporter of iron/sulfur from ER to cytosol, involved in iron homeostasis |
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involved in the transport heme- and/or iron-related compounds from the mitochondrial matrix into the cytosol and in regulation of iron |
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required for mitochondrial porphyrin uptake |
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may be involved in porphyrin transport |
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functionally linked to heme biosynthesis |
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plays a functional role in the plasma membrane |
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involved in haem-precursor transport across the mitochondrial membrane |
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ATP-binding cassette transporter that is highly expressed in cells resistant to arsenic |
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its expression in response to sodium arsenite might be an endogenous protective mechanism activated to protect cells against arsenite-induced oxidative stress |
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mitochondrial transporter that regulates porphyrin biosynthesis |
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plays a role in cell growth and proliferation by targeting the cell cycle |
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mitochondrial porphyrin transporter essential for heme biosynthesis, but it is also suspected to contribute to anticancer drug resistance, as do other ABC transporters located at the plasma membrane |
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having a function in the synthesis of Fe-S clusters and/or iron homeostasis |
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transports potentially a signaling molecule involved in eye development |
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