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FLASH GENE
Symbol PDZD3 contributors: - updated : 26-09-2007
HGNC name PDZ domain containing 3
HGNC id 19891
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four PDZ/DHR domains
  • among which PDZ domain 3 binds with Na-phosphate cotransporter IIa and and PDZ domain 4 with TRPV6
    • HOMOLOGY
    interspecies ortholog to murine Pdzk2
    Homologene
    FAMILY superfamily of class I PDZ proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may inhibit the catalytic activity of GCC by binding to its COOH terminal
  • essential TRPV6 interacting protein as a physiological modulator of TRPV6
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GCC binding
  • interacts with TRPV6 through its fourth PDZ domain
  • interacts with Na-phosphate cotransporter IIa and induced endocytosis of Na-phosphate cotransporter IIa, which in turn result in Na and phosphate excretion in the urine
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS