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FLASH GENE

Symbol

PDZD3

contributors: - updated : 26-09-2007

HGNC name	PDZ domain containing 3
HGNC id	19891

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   intestine small intestine ileum       intestine small intestine jejunum crypt of Lieberkuhn     intestine small intestine duodenum     Urinary kidney       lowly

cells

System Cell Pubmed Species Stage Rna symbol Digestive epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four PDZ/DHR domains
	among which PDZ domain 3 binds with Na-phosphate cotransporter IIa and and PDZ domain 4 with TRPV6

HOMOLOGY

interspecies

ortholog to murine Pdzk2

Homologene

FAMILY

superfamily of class I PDZ proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	may inhibit the catalytic activity of GCC by binding to its COOH terminal
	essential TRPV6 interacting protein as a physiological modulator of TRPV6

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	GCC binding
	interacts with TRPV6 through its fourth PDZ domain
	interacts with Na-phosphate cotransporter IIa and induced endocytosis of Na-phosphate cotransporter IIa, which in turn result in Na and phosphate excretion in the urine

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS