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FLASH GENE
Symbol SPTSSA contributors: mct - updated : 22-11-2016
HGNC name serine palmitoyltransferase small subunit A
HGNC id 19859
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative nuclear localization signal
  • a C2 domain
  • C-terminal domain, which is highly conserved within each subfamily but are the most divergent regions between isoform subfamilies, are not required for activation of the heterodimer or for acyl-CoA selectivity
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in intracellular trafficking and required for exocytosis
  • SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2
  • its role is to increase serine palmitoyltransferase activity without compromising substrate specificity
  • plays a role in fatty acid remodeling of phosphatidylinositol (PI), probably by facilitating the mitochondria-associated membrane (MAM) localization of MBOAT7
  • serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both SPTLC1 and SPTLC2
  • is an MBOAT7-interacting protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS