basic FUNCTION
| may be involved in intracellular trafficking and required for exocytosis |
|
SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2  |
|
its role is to increase serine palmitoyltransferase activity without compromising substrate specificity  |
|
plays a role in fatty acid remodeling of phosphatidylinositol (PI), probably by facilitating the mitochondria-associated membrane (MAM) localization of MBOAT7 |
|
serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length  |