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FLASH GENE
Symbol SPTSSA contributors: mct - updated : 22-11-2016
HGNC name serine palmitoyltransferase small subunit A
HGNC id 19859
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2538 - 71 - 2013 23510452
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Respiratoryrespiratory tracttrachea   
cell lineage
cell lines stomach cancer
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative nuclear localization signal
  • a C2 domain
  • C-terminal domain, which is highly conserved within each subfamily but are the most divergent regions between isoform subfamilies, are not required for activation of the heterodimer or for acyl-CoA selectivity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in intracellular trafficking and required for exocytosis
  • SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2
  • its role is to increase serine palmitoyltransferase activity without compromising substrate specificity
  • plays a role in fatty acid remodeling of phosphatidylinositol (PI), probably by facilitating the mitochondria-associated membrane (MAM) localization of MBOAT7
  • serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both SPTLC1 and SPTLC2
  • is an MBOAT7-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS