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FLASH GENE

Symbol

SPTSSA

contributors: mct - updated : 22-11-2016

HGNC name	serine palmitoyltransferase small subunit A
HGNC id	19859

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.12      Physical location : -
Synonym name	membrane targeting (tandem) C2 domain containing 1
	C2 calcium-dependent domain containing 1
	tandem C2 protein in nucleus
	tandem C2 domains, nuclear
	small subunit of serine palmitoyltransferase A
Synonym symbol(s)	Tac2_N, C14orf47, FLJ36557, c14_5695, MTAC2D1, C2CD1, TC2N, SSSPTA

DNA

TYPE	functioning gene
STRUCTURE	56.00 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138288 2 - 2538 NP_612145 - 71 - 2013 23510452

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Respiratory respiratory tract trachea

cell lineage
cell lines	stomach cancer
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative nuclear localization signal
	a C2 domain
	C-terminal domain, which is highly conserved within each subfamily but are the most divergent regions between isoform subfamilies, are not required for activation of the heterodimer or for acyl-CoA selectivity

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION	may be involved in intracellular trafficking and required for exocytosis
	SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2
	its role is to increase serine palmitoyltransferase activity without compromising substrate specificity
	plays a role in fatty acid remodeling of phosphatidylinositol (PI), probably by facilitating the mitochondria-associated membrane (MAM) localization of MBOAT7
	serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with both SPTLC1 and SPTLC2
	is an MBOAT7-interacting protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS