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FLASH GENE
Symbol SPTSSA contributors: mct - updated : 22-11-2016
HGNC name serine palmitoyltransferase small subunit A
HGNC id 19859
Location 14q32.12      Physical location : -
Synonym name
  • membrane targeting (tandem) C2 domain containing 1
  • C2 calcium-dependent domain containing 1
  • tandem C2 protein in nucleus
  • tandem C2 domains, nuclear
  • small subunit of serine palmitoyltransferase A
  • Synonym symbol(s) Tac2_N, C14orf47, FLJ36557, c14_5695, MTAC2D1, C2CD1, TC2N, SSSPTA
    DNA
    TYPE functioning gene
    STRUCTURE 56.00 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2538 - 71 - 2013 23510452
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea   
    cell lineage
    cell lines stomach cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a putative nuclear localization signal
  • a C2 domain
  • C-terminal domain, which is highly conserved within each subfamily but are the most divergent regions between isoform subfamilies, are not required for activation of the heterodimer or for acyl-CoA selectivity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in intracellular trafficking and required for exocytosis
  • SPTSSA, SPTSSB share a conserved hydrophobic central domain predicted to reside in the membrane, and each interacts with both SPTLC1 and SPTLC2
  • its role is to increase serine palmitoyltransferase activity without compromising substrate specificity
  • plays a role in fatty acid remodeling of phosphatidylinositol (PI), probably by facilitating the mitochondria-associated membrane (MAM) localization of MBOAT7
  • serine palmitoyltransferase (SPT) small subunits (SPTSSA, SPTSSB) play a major role in controlling SPT activity and substrate affinity, and in specifying sphingolipid long chain base (LCB) chain length
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both SPTLC1 and SPTLC2
  • is an MBOAT7-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS