Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAPKAPK3 contributors: - updated : 15-09-2006
HGNC name mitogen-activated protein kinase-activated protein kinase 3
HGNC id 6888
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a protein kinase domain
HOMOLOGY
Homologene
FAMILY Ser/Thr protein kinase family
CATEGORY chaperone/stress , signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK
  • functioning as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TCF3 and with polycomb proteins, such as PCH2 and PCGF4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS