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FLASH GENE

Symbol

MAPKAPK3

contributors: - updated : 15-09-2006

HGNC name	mitogen-activated protein kinase-activated protein kinase 3
HGNC id	6888

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       highly Nervous nerve cranial nerve     highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a protein kinase domain

HOMOLOGY

Homologene

FAMILY

Ser/Thr protein kinase family

CATEGORY

chaperone/stress , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK
	functioning as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with TCF3 and with polycomb proteins, such as PCH2 and PCGF4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in small cell lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS