basic FUNCTION
| possessing an intrinsic histone acetyltransferase activity |
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required in mice for normal growth, puberty, female reproductive function and mammary gland development |
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stimulating gene expression in a hormone dependent fashion, by facilitating the assembly of basal transcription factors into a stable preinitiation complex |
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thyroid hormone receptor activator molecule |
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playing a role in tumorigenesis of breast cancer |
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enhancing Tat-stimulated HIV-1 LTR promoter transactivation |
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involved in coactivation of NFKB pathway via its interaction with NFKB1 subunit |
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acting as a transcription coactivator and a critical regulator of white adipocyte development |
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acting synergistically with CREBBP to control expression of PPARG2 and adipogenesis |
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nuclear receptor co-activator exerting an anti-apoptotic role through a cytoplasmatic action |
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having roles in both steroid-dependent and steroid-independent transcription during tumor progression |
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contributes to the transcription of RARA(RARalpha)-target genes in several cell types |
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served as a ETV4 coactivator and formed complexes with ETV4 on matrix metalloproteinase 2 (MMP2) and MMP9 promoters to enhance their expression in both mouse and human breast cancer cell |
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NCOA1, NCOA2, NCOA3, are not functionally redundant in breast cancer cells because they play gene-specific roles in regulating mRNA and protein expression, and they therefore are likely to make unique contributions to breast tumorigenesis |
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VDR and coactivators NCOA2 and NCOA3, which are also involved in other nuclear receptors as well, are critical for epidermis-specific sphingolipid production and barrier formation |
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coactivator for hormone-activated androgen receptor, may be a prostate cancer oncogene |
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can exert its oncogenicity through tissue-specific estrogen-dependent and estrogen-independent functions |
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with NCOA1 cooperatively regulate placental morphogenesis and embryo survival |
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NCOA2 and NCOA3 concomitantly promote adipocyte differentiation by attenuating phospho-PPARG-S114 and modulating PPARG cellular heterogeneity |
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critical for tumor formation induced by the synovial sarcoma oncoprotein SS18-SSX1 |
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its functions are facilitated by changes in the posttranslational code of the protein that involves mainly phosphorylation and ubiquitination |
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importance of phosphorylation and ubiquitination processes in the regulation of RA target genes through the control of NCOA3 turnover |
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not only contributes to self-renewal by activating NANOG but also facilitates ESC differentiation as a break point to disrupt the core transcriptional circuitry of pluripotency |
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is critical for both the induction and maintenance of pluripotency |