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FLASH GENE
Symbol ZMYND10 contributors: mct/npt - updated : 04-10-2013
HGNC name zinc finger, MYND domain containing 10
HGNC id 19412
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one VWFC domain
  • one MYND-type zinc finger
  • LxxLL motifs
  • a C-terminal fragment that extends beyond the MYND domain is necessary for interaction between ZMYND10 and LRRC6
    • mono polymer trimer
    HOMOLOGY
    interspecies ortholog to rattus zmynd10
    ortholog to murine Zmynd10
    Homologene
    FAMILY
  • fibrillar collagen family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localizes to cytoplasmic puncta in respiratory epithelial cells
    • basic FUNCTION
  • stress-responsive gene, candidate tumor suppressor
  • playing a possible role in the development of esophageal squamous cell carcinomas
  • can functionally suppress tumor formation and is, therefore, likely to be one of the candidate tumor suppressor genes involved in nasopharyngeal carcinoma
  • tumor suppressor that acts as a transcriptional regulator through the association with cellular components
  • can mediate the pro-apoptotic activity through the induction of SMEK1
  • act as a tumor suppressor, inhibits clonogenic growth of nasopharyngeal carcinoma cells, arrests the cell cycle at the G1 phase, downregulates JNK (c-Jun N-terminal kinase) and CCND1 promoter activities, and inhibits phosphorylation of JUN
  • cytoplasmic protein required for inner dynein arms (IDAs) and outer dynein arms (ODAs) assembly
  • its expression correlated exclusively with the development of cells with flagella or motile cilia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • directly interacts with SMEK1, a regulatory subunit of protein phosphatase 4 (N-terminus of ZMYND10 was observed to interact with the C-terminal of SMEK1)
  • ZMYND10 and LRRC6 interact
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    and inversely correlated with promoter hypermethylation in nasopharyngeal carcinoma
    tumoral     --low  
    in some esophageal squamous cell carcinomas
    tumoral     --low  
    by promoter hypermethylation frequently in myelodysplastic syndrom (MDS) cases, especially in higher risk MDS cases
    tumoral     --low  
    in hepatocellular carcinoma by hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS