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FLASH GENE

Symbol

ZMYND10

contributors: mct/npt - updated : 04-10-2013

HGNC name	zinc finger, MYND domain containing 10
HGNC id	19412

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015896 12 - 1780 NP_056980 50.21 440 testis and lung 2004 15122337 isoform 2 - - - - - testis and lung 2013 33891471 differing across 35 centrally positioned amino acids

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Reproductive female system uterus cervix       male system testis       Homo sapiens Respiratory lung         Homo sapiens Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining retinal pigment epithelium (RPE)     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Respiratory ciliari cell Homo sapiens

cell lineage
cell lines	lung cancer cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one VWFC domain
	one MYND-type zinc finger
	LxxLL motifs
	a C-terminal fragment that extends beyond the MYND domain is necessary for interaction between ZMYND10 and LRRC6

mono polymer

trimer

HOMOLOGY

interspecies	ortholog to rattus zmynd10
	ortholog to murine Zmynd10

Homologene

FAMILY

fibrillar collagen family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
text	localizes to cytoplasmic puncta in respiratory epithelial cells

basic FUNCTION	stress-responsive gene, candidate tumor suppressor
	playing a possible role in the development of esophageal squamous cell carcinomas
	can functionally suppress tumor formation and is, therefore, likely to be one of the candidate tumor suppressor genes involved in nasopharyngeal carcinoma
	tumor suppressor that acts as a transcriptional regulator through the association with cellular components
	can mediate the pro-apoptotic activity through the induction of SMEK1
	act as a tumor suppressor, inhibits clonogenic growth of nasopharyngeal carcinoma cells, arrests the cell cycle at the G1 phase, downregulates JNK (c-Jun N-terminal kinase) and CCND1 promoter activities, and inhibits phosphorylation of JUN
	cytoplasmic protein required for inner dynein arms (IDAs) and outer dynein arms (ODAs) assembly
	its expression correlated exclusively with the development of cells with flagella or motile cilia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	directly interacts with SMEK1, a regulatory subunit of protein phosphatase 4 (N-terminus of ZMYND10 was observed to interact with the C-terminal of SMEK1)
	ZMYND10 and LRRC6 interact

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   and inversely correlated with promoter hypermethylation in nasopharyngeal carcinoma tumoral     --low   in some esophageal squamous cell carcinomas tumoral     --low   by promoter hypermethylation frequently in myelodysplastic syndrom (MDS) cases, especially in higher risk MDS cases tumoral     --low   in hepatocellular carcinoma by hypermethylation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS