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FLASH GENE

Symbol

PPM1F

contributors: mct - updated : 17-07-2008

HGNC name	protein phosphatase 1F (PP2C domain containing)
HGNC id	19388

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q11.22      Physical location : 22.273.791 - 22.307.250
Synonym name	PP2C phosphatase
	partner of PIX 2
	CaM-kinase phosphatase
	Ca(2+)/calmodulin-dependent protein kinase phosphatase
Synonym symbol(s)	FEM-2, POPX2, CaMKPase, KIAA0015, CAMKP
EC.number	3.1.3.16

DNA

TYPE	functioning gene
STRUCTURE	33.00 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 - 5169 - 454 - Harvey (2004)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive pancreas exocrine         Lymphoid/Immune spleen         Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines	immature myeloid cell line KG-1
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal region plying important roles in the formation of the catalytically active structure of the enzyme
	C-terminal region important for the maintenance of the catalytically active conformation

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to murine Ppm1f
	homolog to C.elegans FEM2

Homologene

FAMILY

PP2C family of ser/thr protein phosphatases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	negative regulator of cell stress responses
	dephosphorylates and deactivates CAMKII, CAMKIV and CAMKI
	mediates caspase-dependent apoptosis when it is overexpressed maybe through a signaling pathway involving Bcl-XL and caspase-9
	can interact with Rho guanine nucleotide exchange factors and block the effect of p21-activated kinase 1 (PAK1)
	can regulate the activity of CAMK2A (dephosphorylates the critical autophosphorylation site of CAMK2A) and may play a key role in the regulation of the kinase intracellularly

CELLULAR PROCESS	cell life, cell death/apoptosis
	protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

could form an heterotrimeric complex with PPM1E and PAK1

INTERACTION

DNA

RNA

small molecule	metal binding,
	binding two Mg2+ or Mn2+ ions

protein

interacting with Rho guanine nucleotide exchange factors

cell & other

REGULATION

repressed by

HIV-1 Tat in immature dendritic cells, allowing the expansion of HIV-1 infection

Other

Ca2+/Calmodulin dependent activity

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS