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FLASH GENE
Symbol LPP contributors: mct - updated : 28-03-2012
HGNC name LIM domain containing preferred translocation partner in lipoma
HGNC id 6679
Location 3q28      Physical location : 187.871.662 - 188.608.459
Synonym name lipoma-preferred-partner
DNA
TYPE functioning gene
STRUCTURE 736.80 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
text
  • expression of LPP in smooth muscle is mediated by an alternative promoter that is regulated by SRF/MYOCD (PMID: 18511849)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 17747 - 465 - 2009 18511849
    11 - 18278 - 612 - 2009 18511849
    11 - 18221 - 612 - 2009 18511849
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  specific Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • proline rich protein with a N-terminal leucine zipper motif
  • three C-terminal cystein-rich LIM/double finger motifs
  • HOMOLOGY
    Homologene
    FAMILY LIM domain protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,telomere
    text
  • TRIP6 and LPP, detected at a small subset of telomeres, perhaps those that are critically short
  • localizes to focal adhesions/dense bodies
  • basic FUNCTION
  • may play a structural role at sites of cell adhesion in maintaining cell shape and motility
  • may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites
  • plays a role in smooth muscle cell migration
  • zyxin-related cell adhesion protein that is involved in the regulation of cell migration
  • enhancing cell migration
  • specific LIM proteins (TRIP6 and LPP) are part of complex events occurring in the context of the telomere dysfunction response, and possibly at play during the induction of senescence
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin
  • coactivator for the ETS domain transcription factor ETV4
  • cell & other
    REGULATION
    Other directly regulated by serum response factor (SRF)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with HMGIC in benign lipoma t(3;12) (q27;q15) and with C12orf9 in benign mesenchymal tumor t(3;12) (q27;q14)
    tumoral fusion      
    fusion with HMGA2 in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15)
    tumoral     --over  
    in malignancies such as lung carcinoma, soft tissue sarcoma, and leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lpp(-/-) mouse embryonic fibroblasts exhibited reduced migration capacity, reduced viability, and reduced expression of some Lpp interaction partners