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FLASH GENE
Symbol MDGA1 contributors: mct - updated : 11-07-2014
HGNC name MAM domain containing glycosylphosphatidylinositol anchor 1
HGNC id 19267
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six immunoglobulin-like (Ig-like) domains
  • one fibronectin type III domain
  • one MAM domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus LOC309659
    ortholog to murine Mdga1 (90 pc)
    Homologene
    FAMILY GPI-anchored immunoglobulin superfamily
    CATEGORY adhesion , secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • attached to the eukaryotic cell membrane by a GPI (Glycosylphosphatidylinositol) anchor and localized specifically into membrane microdomains known as lipid rafts
    • basic FUNCTION
  • may be involved in tumor progression
  • has critical functions in forebrain/midbrain development
  • acts cell autonomously to control the migration of MDGA1-expressing superficial layer cortical neurons
  • functions in MDGA1-expressing nerves en route to and at their target site
  • is involved in the migration and positioning of a subset of cortical neurons, suggesrting that the radial migration of upper-layer neurons might be differentially regulated
  • mediates cell-cell adhesiveness in a heterophilic manner
  • MDGA1 and MDGA2 are Ig superfamily adhesion molecules
  • MDGA1, MDGA2 regulate inhibitory synapses via their direct interaction with NLGN2
  • is one of few identified negative regulators of synapse development with a unique selectivity for inhibitory synapses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts heterophilically with axon-rich regions, mainly through its MAM domain, also interacts with differentiating muscle through its N-terminal region, which contains Ig domains
  • MDGA1, MDGA2 bind to NLGN2, a cell-adhesion molecule of inhibitory synapses, but do not bind detectably to NLGN1 or NLGN3
  • MDGA1-inhibited the synapse-promoting activity of NLGN2, without altering neuroligin-2 surface trafficking, by inhibiting interaction of NLGN2 with neurexin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia
  • to bipolar disorder
    • Variant & Polymorphism SNP
  • C-C haplotype of rs11759115-rs7769372 was positively associated with schizophrenia
  • Rs1883901 was found to be positively associated with bipolar disorder
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS