basic FUNCTION
| may be involved in tumor progression |
|
has critical functions in forebrain/midbrain development |
|
acts cell autonomously to control the migration of MDGA1-expressing superficial layer cortical neurons |
|
functions in MDGA1-expressing nerves en route to and at their target site |
|
is involved in the migration and positioning of a subset of cortical neurons, suggesrting that the radial migration of upper-layer neurons might be differentially regulated |
|
mediates cell-cell adhesiveness in a heterophilic manner |
|
MDGA1 and MDGA2 are Ig superfamily adhesion molecules |
|
MDGA1, MDGA2 regulate inhibitory synapses via their direct interaction with NLGN2 |
|
is one of few identified negative regulators of synapse development with a unique selectivity for inhibitory synapses |