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FLASH GENE
Symbol MTO1 contributors: mct/npt/pgu - updated : 07-01-2015
HGNC name mitochondrial translation optimization 1 homolog (S. cerevisiae)
HGNC id 19261
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated FlavoP
HOMOLOGY
interspecies homolog to rattus Mto1 (82.2 pc)
homolog to murine Mto1 (87.4 pc)
Homologene
FAMILY
  • gidA family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • apparently involved in translation
  • acting as a disulfide oxidoreductase
  • may play an important role in the pathogenesis of deafness-associated A1555G mutation in 12S rRNA gene or in tRNA genes
  • involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs
  • may modulate the phenotypic manifestation of deafness-associated mitochondrial mutation
  • involved in posttranscriptional modification of mitochondrial tRNAs (mt-tRNAs)
  • FAD-containing enzyme involved in posttranscriptional modification of specific mt-tRNAs, thus contributing to the optimization of mtDNA-dependent protein synthesis
    • CELLULAR PROCESS nucleotide
    protein
    PHYSIOLOGICAL PROCESS electron transport
    text
  • tRNA processing
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MTO1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS